N-acyl 'quat' pyrrolidinone auxiliary as a chiral amide equivalent via direct aminolysis

A novel route to chiral amides through the efficient, non-racemising, cleavage of N-acyl side chains from a 'Quat' chiral auxiliary using N-centred nucleophiles is described. The synthetic utility of the procedure is then highlighted by the preparation of a range of succinamide and succini...

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Main Authors: Davies, S, Dixon, D
格式: Journal article
语言:English
出版: 2002