Structurally encoded intraclass differences in EphA clusters drive distinct cell responses.
Functional outcomes of ephrin binding to Eph receptors (Ephs) range from cell repulsion to adhesion. Here we used cell collapse and stripe assays, showing contrasting effects of human ephrinA5 binding to EphA2 and EphA4. Despite equivalent ligand binding affinities, EphA4 triggered greater cell coll...
Κύριοι συγγραφείς: | Seiradake, E, Schaupp, A, del Toro Ruiz, D, Kaufmann, R, Mitakidis, N, Harlos, K, Aricescu, A, Klein, R, Jones, E |
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Μορφή: | Journal article |
Γλώσσα: | English |
Έκδοση: |
2013
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Παρόμοια τεκμήρια
Παρόμοια τεκμήρια
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Structurally encoded intraclass differences in EphA clusters drive distinct cell responses
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Interactions of the EphA2 kinase domain with PIPs in membranes: implications for receptor function
ανά: Chavent, M, κ.ά.
Έκδοση: (2018)