Structurally encoded intraclass differences in EphA clusters drive distinct cell responses.

Structurally encoded intraclass differences in EphA clusters drive distinct cell responses.

Show other versions (1)

Functional outcomes of ephrin binding to Eph receptors (Ephs) range from cell repulsion to adhesion. Here we used cell collapse and stripe assays, showing contrasting effects of human ephrinA5 binding to EphA2 and EphA4. Despite equivalent ligand binding affinities, EphA4 triggered greater cell coll...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Seiradake, E, Schaupp, A, del Toro Ruiz, D, Kaufmann, R, Mitakidis, N, Harlos, K, Aricescu, A, Klein, R, Jones, E
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	2013

Antzeko izenburuak

Structurally encoded intraclass differences in EphA clusters drive distinct cell responses
nork: Seiradake, E, et al.
Argitaratua: (2013)

Structures of the EphA2 receptor at the membrane: Role of lipid interactions
nork: Chavent, M, et al.
Argitaratua: (2017)

An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly.
nork: Seiradake, E, et al.
Argitaratua: (2010)

Ephrin Receptors (Eph): EphA1, EphA5, and EphA7 Expression in Uveal Melanoma—Associations with Clinical Parameters and Patient Survival
nork: Malgorzata Gajdzis, et al.
Argitaratua: (2020-09-01)

Interactions of the EphA2 kinase domain with PIPs in membranes: implications for receptor function
nork: Chavent, M, et al.
Argitaratua: (2018)

Targeting EphA2 in cancer
nork: Ta Xiao, et al.
Argitaratua: (2020-08-01)

EphA2 Is a Therapy Target in EphA2-Positive Leukemias but Is Not Essential for Normal Hematopoiesis or Leukemia.
nork: Sara Charmsaz, et al.
Argitaratua: (2015-01-01)

Development of an In-House EphA2 ELISA for Human Serum and Measurement of Circulating Levels of EphA2 in Hypertensive Patients with Renal Dysfunction
nork: Maki Murakoshi, et al.
Argitaratua: (2022-12-01)

Patterned Substrate of Mobile and Immobile Ligands to Probe EphA2 Receptor Clustering
nork: Zhongwen Chen, et al.
Argitaratua: (2022-06-01)

Author Correction: The EphA2 receptor is activated through induction of distinct, ligand-dependent oligomeric structures
nork: Deo R. Singh, et al.
Argitaratua: (2018-04-01)

Preclinical and Toxicology Assessment of ALW-II-41-27, an Inhibitor of the Eph Receptor A2 (EphA2)
nork: Theodore J. Kottom, et al.
Argitaratua: (2024-08-01)

EphA7 isoforms differentially regulate cortical dendrite development.
nork: Carrie E Leonard, et al.
Argitaratua: (2020-01-01)

Upregulation of EphA Receptor Expression in the Injured Adult Rat Spinal Cord
nork: Christopher A. Willson, et al.
Argitaratua: (2002-04-01)

Role of EphA4 and EphrinB3 in local neuronal circuits that control walking.
nork: Kullander, K, et al.
Argitaratua: (2003)

Effects of Eph/ephrin signalling and human Alzheimer's disease-associated EphA1 on Drosophila behaviour and neurophysiology
nork: Edgar Buhl, et al.
Argitaratua: (2022-08-01)

Targeting the EphA2 pathway: could it be the way for bone sarcomas?
nork: Giorgia Giordano, et al.
Argitaratua: (2024-09-01)

EphA‐Mediated Regulation of Stomatin Expression in Prostate Cancer Cells
nork: Masanari Nishida, et al.
Argitaratua: (2024-10-01)

Theoretical Model of EphA2-Ephrin A1 Inhibition
nork: Wiktoria Jedwabny, et al.
Argitaratua: (2018-07-01)

Inhibition of VEGF-Dependent Multistage Carcinogenesis by Soluble EphA Receptors
nork: Nikki Cheng, et al.
Argitaratua: (2003-09-01)

Optimizing EphA2-CAR T Cells for the Adoptive Immunotherapy of Glioma
nork: Zhongzhen Yi, et al.
Argitaratua: (2018-06-01)

Anti-EphA2 Antibodies Decrease EphA2 Protein Levels in Murine CT26 Colorectal and Human MDA-231 Breast Tumors But Do Not Inhibit Tumor Growth
nork: David Kiewlich, et al.
Argitaratua: (2006-01-01)

COMPLEMENTARY EXPRESSION OF EphA7 AND SCO-SPONDIN DURING POSTERIOR COMMISSURE DEVELOPMENT
nork: Karen eStanic, et al.
Argitaratua: (2014-06-01)

Drug-resistant cancer cell-derived exosomal EphA2 promotes breast cancer metastasis via the EphA2-Ephrin A1 reverse signaling
nork: Zicong Gao, et al.
Argitaratua: (2021-04-01)

EphA2 contributes to disruption of the blood-brain barrier in cerebral malaria.
nork: Thayer K Darling, et al.
Argitaratua: (2020-01-01)

Probing the effect of clustering on EphA2 receptor signaling efficiency by subcellular control of ligand-receptor mobility
nork: Zhongwen Chen, et al.
Argitaratua: (2021-08-01)

EphA4 defines a class of excitatory locomotor-related interneurons.
nork: Butt, S, et al.
Argitaratua: (2005)

Unveiling the therapeutic promise of EphA2 in glioblastoma: a comprehensive review
nork: Caohang Qiu, et al.
Argitaratua: (2024-09-01)

EphA3 CAR T cells are effective against glioblastoma in preclinical models
nork: Xiang Li, et al.
Argitaratua: (2024-08-01)

#50. Investigating the role of EphA2 in breast cancer bone metastasis
nork: Verra Ngwa, et al.
Argitaratua: (2024-04-01)

Effective Tumor Targeting by EphA2-Agonist-Biotin-Streptavidin Conjugates
nork: Parima Udompholkul, et al.
Argitaratua: (2021-06-01)

EphA7 promotes myogenic differentiation via cell-cell contact
nork: Laura L Arnold, et al.
Argitaratua: (2020-04-01)

Role of EphA2 in host defense against oro-pharyngeal candidiasis
nork: Ingar Olsen
Argitaratua: (2020-01-01)

Engineering of monobody conjugates for human EphA2-specific optical imaging.
nork: Min-A Kim, et al.
Argitaratua: (2017-01-01)

Peripheral loss of EphA4 ameliorates TBI-induced neuroinflammation and tissue damage
nork: Elizabeth A. Kowalski, et al.
Argitaratua: (2019-11-01)

EphA5 Silencing Increases the Radiosensitivity of ESCC Cells Through ATM-Dependent Pathway
nork: Zhang R, et al.
Argitaratua: (2020-10-01)

Therapeutic Targeting of Pancreatic Cancer via EphA2 Dimeric Agonistic Agents
nork: Ahmed F. Salem, et al.
Argitaratua: (2020-05-01)

EphA2 is a functional entry receptor for HCMV infection of glioblastoma cells.
nork: Xiao-Dong Dong, et al.
Argitaratua: (2023-05-01)

Overexpression of hepatocyte EphA2 enhances liver-stage infection by Plasmodium vivax
nork: Sittinont Chainarin, et al.
Argitaratua: (2022-12-01)

Modeling development in retinal afferents: retinotopy, segregation, and ephrinA/EphA mutants.
nork: Keith B Godfrey, et al.
Argitaratua: (2014-01-01)

The identification and validation of EphA7 hypermethylation, a novel biomarker, in cervical cancer
nork: Wenfan Zhang, et al.
Argitaratua: (2022-06-01)