Structurally encoded intraclass differences in EphA clusters drive distinct cell responses.

Structurally encoded intraclass differences in EphA clusters drive distinct cell responses.

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Functional outcomes of ephrin binding to Eph receptors (Ephs) range from cell repulsion to adhesion. Here we used cell collapse and stripe assays, showing contrasting effects of human ephrinA5 binding to EphA2 and EphA4. Despite equivalent ligand binding affinities, EphA4 triggered greater cell coll...

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Main Authors:	Seiradake, E, Schaupp, A, del Toro Ruiz, D, Kaufmann, R, Mitakidis, N, Harlos, K, Aricescu, A, Klein, R, Jones, E
格式:	Journal article
语言:	English
出版:	2013

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