Effect of BET missense mutations on bromodomain function, inhibitor binding and stability

Lysine acetylation is an important epigenetic mark regulating gene transcription and chromatin structure. Acetylated lysine residues are specifically recognized by bromodomains, small protein interaction modules that read these modification in a sequence and acetylation dependent way regulating the...

Volledige beschrijving

Bibliografische gegevens
Hoofdauteurs: Lori, L, Pasquo, A, Lori, C, Petrosino, M, Chiaraluce, R, Tallant, C, Knapp, S, Consalvi, V
Andere auteurs: Kashanchi, F
Formaat: Journal article
Taal:English
Gepubliceerd in: Public Library of Science 2016