Role of ITAM signaling module in signal integration
Diverse cell types use a small number of evolutionarily conserved signaling modules to integrate external cues and elicit distinct functions. A question thus arises as to how does a receptor, which contains a single signaling module, produce distinct outcomes to diverse signals, particularly if such...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2012
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| _version_ | 1826290374680772608 |
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| author | Bezbradica, J Medzhitov, R |
| author_facet | Bezbradica, J Medzhitov, R |
| author_sort | Bezbradica, J |
| collection | OXFORD |
| description | Diverse cell types use a small number of evolutionarily conserved signaling modules to integrate external cues and elicit distinct functions. A question thus arises as to how does a receptor, which contains a single signaling module, produce distinct outcomes to diverse signals, particularly if such module is shared amongst a family of receptors? Emerging data suggest that many immunoreceptors, all of which use a conserved ITAM-module for their signaling, can couple with members of additional classes of membrane receptors to deliver unique signal(s) to the cell. We discuss the possible biological purposes and mechanisms behind these interactions at the plasma membrane. We offer a conceptual framework to understand information processing within the immune system and discuss the new biology of old receptors involving their structural and functional collaborations that evolved to deliver unique signal(s) to the cell using a limited set of conserved signaling modules. |
| first_indexed | 2024-03-07T02:43:13Z |
| format | Journal article |
| id | oxford-uuid:ab294495-97c9-4cc5-9da2-7b409fbb5345 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:43:13Z |
| publishDate | 2012 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:ab294495-97c9-4cc5-9da2-7b409fbb53452022-03-27T03:20:04ZRole of ITAM signaling module in signal integrationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ab294495-97c9-4cc5-9da2-7b409fbb5345EnglishSymplectic Elements at OxfordElsevier2012Bezbradica, JMedzhitov, RDiverse cell types use a small number of evolutionarily conserved signaling modules to integrate external cues and elicit distinct functions. A question thus arises as to how does a receptor, which contains a single signaling module, produce distinct outcomes to diverse signals, particularly if such module is shared amongst a family of receptors? Emerging data suggest that many immunoreceptors, all of which use a conserved ITAM-module for their signaling, can couple with members of additional classes of membrane receptors to deliver unique signal(s) to the cell. We discuss the possible biological purposes and mechanisms behind these interactions at the plasma membrane. We offer a conceptual framework to understand information processing within the immune system and discuss the new biology of old receptors involving their structural and functional collaborations that evolved to deliver unique signal(s) to the cell using a limited set of conserved signaling modules. |
| spellingShingle | Bezbradica, J Medzhitov, R Role of ITAM signaling module in signal integration |
| title | Role of ITAM signaling module in signal integration |
| title_full | Role of ITAM signaling module in signal integration |
| title_fullStr | Role of ITAM signaling module in signal integration |
| title_full_unstemmed | Role of ITAM signaling module in signal integration |
| title_short | Role of ITAM signaling module in signal integration |
| title_sort | role of itam signaling module in signal integration |
| work_keys_str_mv | AT bezbradicaj roleofitamsignalingmoduleinsignalintegration AT medzhitovr roleofitamsignalingmoduleinsignalintegration |