Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2).

"Regulator of G-protein signaling" (RGS) proteins facilitate the termination of G protein-coupled receptor (GPCR) signaling via their ability to increase the intrinsic GTP hydrolysis rate of Galpha subunits (known as GTPase-accelerating protein or "GAP" activity). RGS2 is unique...

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Bibliographic Details
Main Authors: Kimple, A, Soundararajan, M, Hutsell, S, Roos, A, Urban, D, Setola, V, Temple, B, Roth, B, Knapp, S, Willard, F, Siderovski, D
Format: Journal article
Language:English
Published: 2009