Crystal structures of HIV-1 reverse transcriptase mutated at codons 100, 106 and 108 show nevirapine resistance is mediated via perturbation of interactions with Tyr181 or Tyr188

Liknande verk

• Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors.
  av: Ren, J, et al.
  Publicerad: (2004)
• Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors.
  av: Ren, J, et al.
  Publicerad: (2001)
• Relationship of potency and resilience to drug resistant mutations for GW420867X revealed by crystal structures of inhibitor complexes for wild-type, Leu100Ile, Lys101Glu, and Tyr188Cys mutant HIV-1 reverse transcriptases.
  av: Ren, J, et al.
  Publicerad: (2007)
• Mutational analysis of Tyr-318 within the non-nucleoside reverse transcriptase inhibitor binding pocket of human immunodeficiency virus type I reverse transcriptase.
  av: Pelemans, H, et al.
  Publicerad: (1998)
• Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138.
  av: Ren, J, et al.
  Publicerad: (2006)