Molecular flexibility of DNA as a key determinant of RAD51 recruitment

The timely activation of homologous recombination is essential for the maintenance of genome stability, in which the RAD51 recombinase plays a central role. Biochemically, human RAD51 polymerises faster on single‐stranded DNA (ssDNA) compared to double‐stranded DNA (dsDNA), raising a key conceptual...

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Bibliographic Details
Main Authors: Paoletti, F, El-Sagheer, AH, Allard, J, Brown, T, Dushek, O, Esashi, F
Format: Journal article
Language:English
Published: EMBO Press 2020