Glutamate acts as a key signal linking glucose metabolism to incretin/cAMP action to amplify insulin secretion.

Glutamate acts as a key signal linking glucose metabolism to incretin/cAMP action to amplify insulin secretion.

Incretins, hormones released by the gut after meal ingestion, are essential for maintaining systemic glucose homeostasis by stimulating insulin secretion. The effect of incretins on insulin secretion occurs only at elevated glucose concentrations and is mediated by cAMP signaling, but the mechanism ...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Gheni, G, Ogura, M, Iwasaki, M, Yokoi, N, Minami, K, Nakayama, Y, Harada, K, Hastoy, B, Wu, X, Takahashi, H, Kimura, K, Matsubara, T, Hoshikawa, R, Hatano, N, Sugawara, K, Shibasaki, T, Inagaki, N, Bamba, T, Mizoguchi, A, Fukusaki, E, Rorsman, P, Seino, S
Format: Journal article
Sprache:English
Veröffentlicht: Elsevier 2014

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