Immunological intervention reveals reciprocal roles for tumor necrosis factor-alpha and interleukin-10 in rheumatoid arthritis and systemic lupus erythematosus.
In RA (and in collagen-induced arthritis in DBA/l mice) experimental evidence has convincingly demonstrated the therapeutic benefit of anti-TNF-α antibodies, whereas anti-TNF-α also induces lupus-associated DNA antibodies in a minority of presumably genetically susceptible individuals, and accelerat...
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Springer-Verlag
1994
|