CPT1a-dependent long-chain fatty acid oxidation contributes to maintaining glucagon secretion from pancreatic islets

Glucagon, the principal hyperglycemic hormone, is secreted from pancreatic islet α cells as part of the counter-regulatory response to hypoglycemia. Hence, secretory output from α cells is under high demand in conditions of low glucose supply. Many tissues oxidize fat as an alternate energy substrat...

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Bibliographic Details
Main Authors: Briant, LJB, Dodd, MS, Chibalina, MV, Rorsman, NJG, Johnson, PRV, Carmaliet, P, Rorsman, P, Knudsen, JG
Format: Journal article
Published: Cell Press 2018