Repeat expansions confer WRN dependence in microsatellite-unstable cancers

Repeat expansions confer WRN dependence in microsatellite-unstable cancers

The RecQ DNA helicase WRN is a synthetic lethal target for cancer cells with microsatellite instability (MSI), a form of genetic hypermutability that arises from impaired mismatch repair. Depletion of WRN induces widespread DNA double-strand breaks in MSI cells, leading to cell cycle arrest and/or a...

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Main Authors: van Wietmarschen, N, Sridharan, S, Nathan, WJ, Tubbs, A, Chan, EM, Callen, E, Wu, W, Belinky, F, Tripathi, V, Wong, N, Foster, K, Noorbakhsh, J, Garimella, K, Cruz-Migoni, A, Sommers, JA, Huang, Y, Borah, AA, Smith, JT, Kalfon, J, Kesten, N, Fugger, K, Walker, RL, Dolzhenko, E, Eberle, MA, Hayward, BE, Usdin, K, Freudenreich, CH, Brosh, RM, West, SC, McHugh, PJ, Meltzer, PS, Bass, AJ, Nussenzweig, A
Format: Journal article
Language:English
Published: Springer Nature 2020

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