Tryptophan 2,3-dioxygenase expression identified in human hepatocellular carcinoma cells and in intratumoral pericytes of most cancers

Tryptophan 2,3-dioxygenase expression identified in human hepatocellular carcinoma cells and in intratumoral pericytes of most cancers

Tryptophan catabolism is used by tumors to resist immune attack. It can be catalyzed by indoleamine 2,3-dioxygenase (IDO1) and tryptophan 2,3-dioxygenase (TDO). IDO1 is frequently expressed in tumors and has been widely studied as a potential therapeutic target to reduce resistance to cancer immunot...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Hoffmann, D, Dvorakova, T, Stroobant, V, Bouzin, C, Daumerie, A, Solvay, M, Klaessens, S, Letellier, M-C, Renauld, J-C, van Baren, N, Lelotte, J, Marbaix, E, Van den Eynde, BJ
Format: Journal article
Sprache:English
Veröffentlicht: American Association for Cancer Research 2019

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