Choosing the target difference ('effect size') for a randomised controlled trial - DELTA(2) guidance protocol.
<p>BACKGROUND: A key step in the design of a randomised controlled trial (RCT) is the estimation of the number of participants needed. By far the most common approach is to specify a target difference and then estimate the corresponding sample size; this sample size is chosen to provide reassu...
Autori principali: | Cook, JA, Julious, SA, Sones, W, Rothwell, JC, Ramsay, CR, Hampson, LV, Emsley, R, Walters, SJ, Hewitt, C, Bland, M, Fergusson, DA, Berlin, JA, Altman, D, Vale, LD |
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Natura: | Journal article |
Lingua: | English |
Pubblicazione: |
BioMed Central
2017
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