Investigation of the biological function of arginine methyltransferase PRMT5 in human cancers

<p>PRMT5 is a major type II arginine methyltransferase and plays a crucial role in tumorigenesis. PRMT5 is overexpressed in multiple tumour cell lines, and a high level of PRMT5 was identified as an independent factor for poor clinical outcomes in patients with cancer. PRMT5 has been identifie...

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Bibliographic Details
Main Author: Jin, L
Other Authors: La Thangue, N
Format: Thesis
Language:English
Published: 2020