Association between a selective 5-HT4 receptor agonist and incidence of major depressive disorder: emulated target trial

<p><b>Background</b></p> The serotonin 4 receptor (5-HT4R) is a promising target for the treatment of depression. Highly selective 5-HT4R agonists, such as prucalopride, have antidepressant-like and procognitive effects in preclinical models, but their clinical effects are no...

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Bibliographic Details
Main Authors: de Cates, AN, Harmer, CJ, Harrison, PJ, Cowen, PJ, Emmanuel, A, Travis, S, Murphy, SE, Taquet, M
Format: Journal article
Language:English
Published: Cambridge University Press 2024