The effect of lactate and pH on proteoglycan and protein synthesis rates in the intervertebral disc.

The intervertebral disc is the largest avascular tissue in the body. Its metabolism is mainly anaerobic, and thus lactate is produced at a significant rate. As a result the lactate concentrations in the center of the disc may be 8-10 times as high as in the plasma. The pH in the disc center is thus...

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Bibliographic Details
Main Authors: Ohshima, H, Urban, J
Format: Journal article
Language:English
Published: 1992