Antibody multispecificity mediated by conformational diversity.
A single antibody was shown to adopt different binding-site conformations and thereby bind unrelated antigens. Analysis by both x-ray crystallography and pre-steady-state kinetics revealed an equilibrium between different preexisting isomers, one of which possessed a promiscuous, low-affinity bindin...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2003
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