Fine mapping of candidate effector genes for heart rate

An elevated resting heart rate (RHR) is associated with increased cardiovascular mortality. Genome-wide association studies (GWAS) have identified > 350 loci. Uniquely, in this study we applied genetic fine-mapping leveraging tissue specific chromatin segmentation and colocalization analyses to i...

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Bibliographic Details
Main Authors: Ramírez, J, van Duijvenboden, S, Young, WJ, Chen, Y, Usman, T, Orini, M, Lambiase, PD, Tinker, A, Bell, CG, Morris, AP, Munroe, PB
Format: Journal article
Language:English
Published: Springer 2024