Abnormal cardiac morphology, function and energy metabolism in the dystrophic mdx mouse: an MRI and MRS study.

Abnormal cardiac morphology, function and energy metabolism in the dystrophic mdx mouse: an MRI and MRS study.

Patients with muscular dystrophy have abnormal cardiac function and decreased high-energy phosphate metabolism. Here, we have determined whether the 8 month old mdx mouse, an animal model of muscular dystrophy, also has abnormal cardiac function and energetics. In vivo cardiac MRI revealed 33% and 1...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Zhang, W, ten Hove, M, Schneider, J, Stuckey, D, Sebag-Montefiore, L, Bia, B, Radda, G, Davies, K, Neubauer, S, Clarke, K
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2008

Παρόμοια τεκμήρια

Up-regulation of utrophin alleviates the dystrophic phenotype in the mdx mouse heart
ανά: Sang, E, κ.ά.
Έκδοση: (2000)

Increased susceptibility of the dystrophic mdx mouse heart to ischemic and hypoxic injuries
ανά: Zhang, W, κ.ά.
Έκδοση: (2005)

In vivo cardiac 1H-MRS in the mouse.
ανά: Schneider, J, κ.ά.
Έκδοση: (2004)

In vivo MRI characterization of progressive cardiac dysfunction in the mdx mouse model of muscular dystrophy.
ανά: Stuckey, D, κ.ά.
Έκδοση: (2012)

T-cell-dependent fibrosis in the mdx dystrophic mouse.
ανά: Morrison, J, κ.ά.
Έκδοση: (2000)

Decrease in prosaposin in the Dystrophic mdx mouse brain.
ανά: Hui-Ling Gao, κ.ά.
Έκδοση: (2013-01-01)

Increased mitochondrial uncoupling protein 3 is associated with the cardiomyopathy in the dystrophic mouse heart
ανά: Zhang, W, κ.ά.
Έκδοση: (2006)

In vivo MRI characterization of progressive cardiac dysfunction in the mdx mouse model of muscular dystrophy.
ανά: Daniel J Stuckey, κ.ά.
Έκδοση: (2012-01-01)

Data on uncoupling protein-3 levels, hypoxia, low flow ischemia, and insulin stimulation in dystrophin-deficient mdx mouse hearts
ανά: Zhang, W, κ.ά.
Έκδοση: (2018)

PPAR alpha is involved in triiodothyronine-induced cardiac hypertrophy and high-energy phosphate metabolism: A P-31 MRS study of the PPAR alpha-null mouse
ανά: Zhang, W, κ.ά.
Έκδοση: (2006)

Functional amounts of dystrophin produced by skipping the mutated exon in the mdx dystrophic mouse.
ανά: Lu, Q, κ.ά.
Έκδοση: (2003)

Heregulin ameliorates the dystrophic phenotype in mdx mice.
ανά: Krag, T, κ.ά.
Έκδοση: (2004)

Serial high resolution 3D-MRI after aortic banding in mice: band internalization is a source of variability in the hypertrophic response.
ανά: Lygate, C, κ.ά.
Έκδοση: (2006)

Brain metabolism is abnormal in the mdx model of Duchenne muscular dystrophy.
ανά: Tracey, I, κ.ά.
Έκδοση: (1996)

Choline administration attenuates aspects of the dystrophic pathology in mdx mice
ανά: Francesca M. Alves, κ.ά.
Έκδοση: (2019-04-01)

Use of antisense-mediated exon skipping to generate dystrophin in muscles of the mdx dystrophic mouse
ανά: Lu, Q, κ.ά.
Έκδοση: (2004)

Erythropoietin reduces the expression of myostatin in mdx dystrophic mice
ανά: D. Feder, κ.ά.
Έκδοση: (2014-11-01)

l-arginine improves dystrophic phenotype in mdx mice
ανά: Vincent Voisin, κ.ά.
Έκδοση: (2005-10-01)

An in vivo and in vitro H-magnetic resonance spectroscopy study of mdx mouse brain: abnormal development or neural necrosis?
ανά: Tracey, I, κ.ά.
Έκδοση: (1996)

Data on uncoupling protein-3 levels, hypoxia, low flow ischemia, and insulin stimulation in dystrophin-deficient mdx mouse hearts
ανά: Wen Zhang, κ.ά.
Έκδοση: (2018-10-01)

Mutation types and aging differently affect revertant fiber expansion in dystrophic mdx and mdx52 mice.
ανά: Yusuke Echigoya, κ.ά.
Έκδοση: (2013-01-01)

Dystrophic phenotype improvement in the diaphragm muscle of mdx mice by diacerhein.
ανά: Rafael Dias Mâncio, κ.ά.
Έκδοση: (2017-01-01)

Proteome Profiling of the Dystrophic <i>mdx</i> Mice Diaphragm
ανά: Olga Mucha, κ.ά.
Έκδοση: (2023-11-01)

Dysfunctional muscle and liver glycogen metabolism in mdx dystrophic mice.
ανά: David I Stapleton, κ.ά.
Έκδοση: (2014-01-01)

The creatine kinase energy transport system in the failing mouse heart.
ανά: Lygate, C, κ.ά.
Έκδοση: (2007)

A Reduction in Selenoprotein S Amplifies the Inflammatory Profile of Fast-Twitch Skeletal Muscle in the mdx Dystrophic Mouse
ανά: Craig Robert Wright, κ.ά.
Έκδοση: (2017-01-01)

Daily treatment with SMTC1100, a novel small molecule utrophin upregulator, dramatically reduces the dystrophic symptoms in the mdx mouse.
ανά: Tinsley, J, κ.ά.
Έκδοση: (2011)

Non-invasive MRI and spectroscopy of mdx mice reveal temporal changes in dystrophic muscle imaging and in energy deficits.
ανά: Christopher R Heier, κ.ά.
Έκδοση: (2014-01-01)

Lipidomic Analyses Reveal Specific Alterations of Phosphatidylcholine in Dystrophic Mdx Muscle
ανά: William J. Valentine, κ.ά.
Έκδοση: (2022-01-01)

Chronic Dosing with Membrane Sealant Poloxamer 188 NF Improves Respiratory Dysfunction in Dystrophic Mdx and Mdx/Utrophin-/- Mice.
ανά: Bruce E Markham, κ.ά.
Έκδοση: (2015-01-01)

Regulation of myocardial creatine uptake capacity in genetically altered mouse models
ανά: Ten Hove, M, κ.ά.
Έκδοση: (2007)

Daily treatment with SMTC1100, a novel small molecule utrophin upregulator, dramatically reduces the dystrophic symptoms in the mdx mouse.
ανά: Jonathon M Tinsley, κ.ά.
Έκδοση: (2011-05-01)

Resolution of fibrosis in mdx dystrophic mouse after oral consumption of N-163 strain of Aureobasidium pullulans produced β-glucan
ανά: Senthilkumar Preethy, κ.ά.
Έκδοση: (2023-10-01)

Subproteomic profiling of sarcolemma from dystrophic mdx-4cv skeletal muscle
ανά: Sandra Murphy, κ.ά.
Έκδοση: (2018-04-01)

Cardioprotective Effect of Whole Body Periodic Acceleration in Dystrophic Phenotype mdx Rodent
ανά: Arkady Uryash, κ.ά.
Έκδοση: (2021-05-01)

Plectin 1f scaffolding at the sarcolemma of dystrophic (mdx) muscle fibers through multiple interactions with beta-dystroglycan.
ανά: Rezniczek, G, κ.ά.
Έκδοση: (2007)

Extrajunctional resting Ca2+ influx is not increased in a severely dystrophic expiratory muscle (triangularis sterni) of the mdx mouse
ανά: C.George Carlson, κ.ά.
Έκδοση: (2003-11-01)

The BALB/c.mdx62 mouse exhibits a dystrophic muscle pathology and is a model of Duchenne muscular dystrophy
ανά: Kristy Swiderski, κ.ά.
Έκδοση: (2024-04-01)

Expansion of revertant fibers in dystrophic mdx muscles reflects activity of muscle precursor cells and serves as an index of muscle regeneration.
ανά: Yokota, T, κ.ά.
Έκδοση: (2006)

Changes in creatine transporter function during cardiac maturation in the rat.
ανά: Fischer, A, κ.ά.
Έκδοση: (2010)