TRAIL regulatory receptors constrain human hepatic stellate cell apoptosis

The TRAIL pathway can mediate apoptosis of hepatic stellate cells to promote the resolution of liver fibrosis. However, TRAIL has the capacity to bind to regulatory receptors in addition to death-inducing receptors; their differential roles in liver fibrosis have not been investigated. Here we have...

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Bibliographic Details
Main Authors: Singh, HD, Otano, I, Rombouts, K, Singh, KP, Peppa, D, Gill, US, Böttcher, K, Kennedy, PTF, Oben, J, Pinzani, M, Walczak, H, Fusai, G, Rosenberg, WMC, Maini, MK
Format: Journal article
Language:English
Published: Nature Publishing Group 2017