Reduction of cPLA2alpha overexpression: an efficient anti-inflammatory therapy for collagen-induced arthritis.

Reduction of cPLA2alpha overexpression: an efficient anti-inflammatory therapy for collagen-induced arthritis.

Cytosolic phospholipase A2alpha (cPLA2) plays an important role in the development of several inflammatory diseases. The aim of the present study is to determine whether inhibition of cPLA2 expression, using specific antisense oligonucleotides against cPLA2 (antisense), is efficient in reducing infl...

תיאור מלא

מידע ביבליוגרפי
Main Authors:	Raichel, L, Berger, S, Hadad, N, Kachko, L, Karter, M, Szaingurten-Solodkin, I, Williams, R, Feldmann, M, Levy, R
פורמט:	Journal article
שפה:	English
יצא לאור:	2008

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Cytosolic Phospholipase A2(cPLA2) Immunoreactivity Is Elevated in Alzheimer's Disease Brain
מאת: Diane T. Stephenson, et al.
יצא לאור: (1996-02-01)

Interleukin 15 primes natural killer cells to kill via NKG2D and cPLA2 and this pathway is active in psoriatic arthritis.
מאת: Fangming Tang, et al.
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Evaluation of TNF-alpha and IL-1 blockade in collagen-induced arthritis and comparison with combined anti-TNF-alpha/anti-CD4 therapy.
מאת: Williams, R, et al.
יצא לאור: (2000)

Highly Potent 2‑Oxoester Inhibitors of Cytosolic Phospholipase A2 (GIVA cPLA2)
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יצא לאור: (2018-08-01)

A distal enhancer controls cytokine-dependent human cPLA2α gene expression[S]
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Specific monocyte adhesion to endothelial cells induced by oxidized phospholipids involves activation of cPLA2 and lipoxygenase
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Correction to “Highly Potent 2‑Oxoester Inhibitors of Cytosolic Phospholipase A2 (GIVA cPLA2)”
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Involvement of the γ Isoform of cPLA<sub>2</sub> in the Biosynthesis of Bioactive <i>N-</i>Acylethanolamines
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Inhibition of sPLA₂-IIA prevents LPS-induced neuroinflammation by suppressing ERK1/2-cPLA₂α pathway in mice cerebral cortex.
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Suppression of TNF-alpha expression, inhibition of Th1 activity, and amelioration of collagen-induced arthritis by rolipram.
מאת: Ross, SE, et al.
יצא לאור: (1997)

Therapeutic actions of cyclosporine and anti-tumor necrosis factor alpha in collagen-induced arthritis and the effect of combination therapy.
מאת: Williams, R, et al.
יצא לאור: (1998)

Structure Activity Relationship and Molecular Docking of Some Quinazolines Bearing Sulfamerazine Moiety as New 3CLpro, cPLA2, sPLA2 Inhibitors
מאת: Mohammed Abdalla Hussein, et al.
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Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization
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The effects of myelin on macrophage activation are phenotypic specific via cPLA2 in the context of spinal cord injury inflammation
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Inhibition of Cytosolic Phospholipase A2α (cPLA2α) by Medicinal Plants in Relation to Their Phenolic Content
מאת: Eva Arnold, et al.
יצא לאור: (2015-08-01)

Formyl Peptide Receptor 2-Dependent cPLA2 and 5-LOX Activation Requires a Functional NADPH Oxidase
מאת: Tiziana Pecchillo Cimmino, et al.
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Thrombin induces ferroptosis in triple-negative breast cancer through the cPLA2α/ACSL4 signaling pathway
מאת: Shuo Xu, et al.
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cPLA2 phosphorylation at serine-515 and serine-505 is required for arachidonic acid release in vascular smooth muscle cells
מאת: Zoran Pavicevic, et al.
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TNF-alpha-induced cPLA2 expression via NADPH oxidase/reactive oxygen species-dependent NF-kappaB cascade on human pulmonary alveolar epithelial cells
מאת: Chih-Chung Lin, et al.
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Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer’s Disease
מאת: Mikko Gynther, et al.
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Blue light alters cellular lipidome—Light-induced lipidomic changes can be modulated by optogenetically engineered cPLA2α
מאת: Chi Zhang, et al.
יצא לאור: (2022-12-01)

Soluble oligomers of amyloid-β peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway
מאת: Catherine Malaplate-Armand, et al.
יצא לאור: (2006-07-01)

Collagen-induced arthritis in mice: a major role for tumor necrosis factor-alpha.
מאת: Williams, R
יצא לאור: (2007)

Coptisine ameliorates colitis in mice by modulating cPLA2/TRPM8/CGRP-1 signaling pathways and strengthening intestinal barrier function
מאת: Wenbin Wu, et al.
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Alveolar macrophage-derived gVPLA2 promotes ventilator-induced lung injury via the cPLA2/PGE2 pathway
מאת: Hanghang Han, et al.
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Effect of Kaempferol on Cyclooxygenase 2 (Cox2) and Cytosolic Phospholipase A2 (cPLA2) Protein Expression in BALB/c Mice
מאת: Da Rae Kang, et al.
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Gigantol ameliorates CCl4-induced liver injury via preventing activation of JNK/cPLA2/12-LOX inflammatory pathway
מאת: Yaru Xue, et al.
יצא לאור: (2020-12-01)

Suppression of collagen-induced arthritis by continuous administration of IL-4.
מאת: Horsfall, A, et al.
יצא לאור: (1997)

Macrophage-specific overexpression of group IIa sPLA2 increases atherosclerosis and enhances collagen deposition
מאת: Stijn A.I. Ghesquiere, et al.
יצא לאור: (2005-02-01)

Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis.
מאת: Williams, R, et al.
יצא לאור: (1992)

Dynamics of proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis (CIA).
מאת: Marinova-Mutafchieva, L, et al.
יצא לאור: (1997)

Targeting TNF alpha for the therapy of rheumatoid arthritis.
מאת: Maini, R, et al.
יצא לאור: (1994)

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