IL-1RI deficiency ameliorates early experimental renal interstitial fibrosis.
BACKGROUND: IL-1beta has the potential to promote progressive renal disease by effects on macrophage recruitment and activation or by effects mediated through tubular cell transforming growth factor (TGF)-beta production, previously demonstrated in vitro. METHODS: The in vivo roles of endogenous IL...
Main Authors: | Jones, L, O'Sullivan, K, Semple, T, Kuligowski, M, Fukami, K, Ma, F, Nikolic-Paterson, D, Holdsworth, SR, Kitching, A |
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Format: | Journal article |
Jezik: | English |
Izdano: |
2009
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