A non-human primate in vitro functional assay for the early evaluation of TB vaccine candidates

We present a non-human primate mycobacterial growth inhibition assay (MGIA) using in vitro blood or cell co-culture with the aim of refining and expediting early tuberculosis vaccine testing. We have taken steps to optimise the assay using cryopreserved peripheral blood mononuclear cells, transfer i...

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Bibliographic Details
Main Authors: Tanner, R, White, AD, Boot, C, Sombroek, CC, O'Shea, MK, Wright, D, Hoogkamer, E, Bitencourt, J, Harris, SA, Sarfas, C, Wittenberg, R, Satti, I, Fletcher, HA, Verreck, FAW, Sharpe, SA, McShane, H
Format: Journal article
Language:English
Published: Springer Nature 2021