PENICILLIN BIOSYNTHESIS - DEPENDENCE OF SUBSTRATE STEREOCHEMISTRY ON THE MODE OF 2ND RING-CLOSURE
The stereochemical requirements for the conversion of tripeptides with unsaturated amino acids in the C-terminal position to bicyclic β-lactam products using isopenicillin N synthase was investigated using diastereomeric peptides containing 2R,3S-2-amino-3-methylpent-4-enoic acid and 2R,2R-2-amino-3...
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1990
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