Haemoglobin C and S in natural selection against Plasmodium falciparum malaria: a plethora or a single shared adaptive mechanism?

Conclusive evidence exists on the protective role against clinical Plasmodium falciparum malaria of Haemoglobin S (beta 6Glu-->Val) and HbC (HbC; beta 6Glu-->Lys), both occurring in sub-Saharan Africa. However, the mechanism/s of the protection exerted remain/s debated for both haemogl...

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Bibliographic Details
Main Authors: Verra, F, Bancone, G, Avellino, P, Blot, I, Simporé, J, Modiano, D
Format: Journal article
Language:English
Published: 2007