Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

Biological interpretation of genome-wide association study data frequently involves assessing whether SNPs linked to a biological process, for example, binding of a transcription factor, show unsigned enrichment for disease signal. However, signed annotations quantifying whether each SNP allele prom...

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Detalles Bibliográficos
Autores principales:	Reshef, YA, Finucane, H, Kelley, DR, Gusev, A, Kotliar, D, Ulirsch, J, Hormozdiari, F, Nasser, J, O’Connor, L, van de Geijn, B, Loh, PR, Grossman, SR, Bhatia, G, Gazal, S, Pinello, L, Palamara, PF, Patterson, N, Adams, RP, Price, AL
Formato:	Journal article
Publicado:	Nature Publishing Group 2018

Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

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