Competing intrachain interactions regulate the formation of beta-sheet fibrils in bovine PrP peptides.
At the heart of the pathogenesis of transmissible spongiform encephalopathies (TSEs), such as BSE, scrapie, and Creutzfeldt-Jakob disease, lies a poorly understood structural rearrangement of PrP, an abundant glycoprotein of the nervous and lymphoid systems. The normal form (PrP(C)), rich in alpha-h...
| Main Authors: | , , , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
2003
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