Reverse immunodynamics: a new method for identifying targets of protective immunity

Reverse immunodynamics: a new method for identifying targets of protective immunity

Despite a dramatic increase in our ability to catalogue variation among pathogen genomes, we have made far fewer advances in using this information to identify targets of protective immunity. Epidemiological models predict that strong immune selection can cause antigenic variants to structure into g...

Descrizione completa

Dettagli Bibliografici
Autori principali:	Spensley, K, Wikramaratna, P, Penman, B, Walker, A, Smith, A, Pybus, O, Jean, L, Gupta, S, Lourenco, J
Natura:	Journal article
Pubblicazione:	Springer Nature 2019

Documenti analoghi

From immune equilibrium to immunodynamics
di: Xiaoping Chen, et al.
Pubblicazione: (2022-11-01)

Immunodynamics of explanted human tumors for immuno‐oncology
di: Agathe Dubuisson, et al.
Pubblicazione: (2020-12-01)

Radiation immunodynamics in patients with glioblastoma receiving chemoradiation
di: Lindsey Sloan, et al.
Pubblicazione: (2024-09-01)

Endothelin B Receptor Immunodynamics in Pulmonary Arterial Hypertension
di: Christoph Tabeling, et al.
Pubblicazione: (2022-06-01)

Immunostimulatory/Immunodynamic model of mRNA‐1273 to guide pediatric vaccine dose selection
di: Vijay Ivaturi, et al.
Pubblicazione: (2025-01-01)

A first-in-class, non-invasive, immunodynamic biomarker approach for precision immuno-oncology
di: Jenny Sprooten, et al.
Pubblicazione: (2022-12-01)

Loss of CD47 alters CD8+ T cell activation in vitro and immunodynamics in mice
di: Pulak R. Nath, et al.
Pubblicazione: (2022-12-01)

Effects of neutralizing antibodies on escape from CD8+ T-cell responses in HIV-1 infection.
di: Wikramaratna, P, et al.
Pubblicazione: (2015)

Contact between bird species of different lifespans can promote the emergence of highly pathogenic avian influenza strains.
di: Wikramaratna, P, et al.
Pubblicazione: (2014)

Comprehensive analyses of immunodynamics and immunoreactivity in response to treatment in ALK-positive non-small-cell lung cancer
di: Sung Sook Lee, et al.
Pubblicazione: (2020-10-01)

Mathematical Modeling Finds Disparate Interferon Production Rates Drive Strain-Specific Immunodynamics during Deadly Influenza Infection
di: Emily E. Ackerman, et al.
Pubblicazione: (2022-04-01)

Protocol to study immunodynamics in the tumor microenvironment using a tyramide signal amplification-based immunofluorescent multiplex panel
di: Jane Siu-Fan Li, et al.
Pubblicazione: (2024-03-01)

The interplay between environmental factors, vector competence and vaccine immunodynamics as possible explanation of the 2019 yellow fever re-emergence in Nigeria
di: I.N. Abdullahi, et al.
Pubblicazione: (2021-05-01)

Predicting IFN-γ responses after BCG vaccination in humans from macaques: A proof-of-concept study of Immunostimulation/Immunodynamic modelling methods
di: Rhodes, S, et al.
Pubblicazione: (2017)

MANTIS: An R package that simulates multilocus models of pathogen evolution
di: Lourenço, J, et al.
Pubblicazione: (2010)

Epistatic interactions between genetic disorders of hemoglobin can explain why the sickle-cell gene is uncommon in the Mediterranean
di: Penman, B, et al.
Pubblicazione: (2009)

Epistatic interactions between genetic disorders of hemoglobin can explain why the sickle-cell gene is uncommon in the Mediterranean.
di: Penman, B, et al.
Pubblicazione: (2009)

Influenza outbreaks
di: Wikramaratna, P, et al.
Pubblicazione: (2009)

Influenza outbreaks.
di: Wikramaratna, P, et al.
Pubblicazione: (2009)

Targeting innate immunity to downmodulate adaptive immunity and reverse type 1 diabetes
di: Itoh A, et al.
Pubblicazione: (2017-05-01)

A naturally protective epitope of limited variability as an influenza vaccine target
di: Thompson, C, et al.
Pubblicazione: (2018)

Understanding the contrasting spatial haplotype patterns of malaria-protective β-globin polymorphisms
di: Hockham, C, et al.
Pubblicazione: (2015)

Guest editorial: understanding dental pulp innate immunity - a basis for identifying new targets for therapeutic agents that dampen inflammation
di: Jean-Christophe Farges
Pubblicazione: (2009-06-01)

Estimating the false-negative test probability of SARS-CoV-2 by RT-PCR
di: Wikramaratna, PS, et al.
Pubblicazione: (2020)

Prediction of thioredoxin and glutaredoxin target proteins by identifying reversibly oxidized cysteinyl residues
di: Lee Hang-mao, et al.
Pubblicazione: (2010-12-01)

In vivo inducible reverse genetics in patients’ tumors to identify individual therapeutic targets
di: Michela Carlet, et al.
Pubblicazione: (2021-09-01)

The evolution of viral diversity
di: Wikramaratna, P
Pubblicazione: (2012)

A naturally protective epitope of limited variability as an influenza vaccine target
di: Craig P. Thompson, et al.
Pubblicazione: (2018-09-01)

From Renal Biomarkers to Therapeutic Targets: The Use of Monocyte Chemoattractant Protein 1, Transforming Growth Factor-Beta, and Connective Tissue Growth Factor in Diabetic Nephropathy and Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
di: Katrina J Spensley, et al.
Pubblicazione: (2018-12-01)

Protective antigens against glanders identified by expression library immunization
di: Gregory C. Whitlock, et al.
Pubblicazione: (2011-11-01)

High-Throughput Antibody Profiling Identifies Targets of Protective Immunity against <i>P. falciparum</i> Malaria in Thailand
di: Ifra Hassan, et al.
Pubblicazione: (2023-08-01)

A reverse vaccinology approach identifies putative vaccination targets in the zoonotic nematode Ascaris
di: Francisco M. D. Evangelista, et al.
Pubblicazione: (2022-11-01)

The antigenic evolution of influenza: drift or thrift?
di: Wikramaratna, P, et al.
Pubblicazione: (2013)

The effects of tertiary and quaternary infections on the epidemiology of dengue.
di: Wikramaratna, P, et al.
Pubblicazione: (2010)

The antigenic evolution of influenza: drift or thrift?
di: Wikramaratna, P, et al.
Pubblicazione: (2013)

Identifying asynchronies: Reverse trigger
di: Víctor Perez, et al.
Pubblicazione: (2022-06-01)

Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice
di: Ayana N. Martin, et al.
Pubblicazione: (2018-01-01)

Targeting Cancer Cell Ferroptosis to Reverse Immune Checkpoint Inhibitor Therapy Resistance
di: Jingjing Deng, et al.
Pubblicazione: (2022-03-01)

Proteomic analysis of Kveim reagent identifies targets of cellular immunity in sarcoidosis
di: Eberhardt, C, et al.
Pubblicazione: (2017)

Adaptive immunity selects against malaria infection blocking mutations.
di: Bridget S Penman, et al.
Pubblicazione: (2020-10-01)