Cytomegalovirus infection in Gambian infants leads to profound CD8 T-cell differentiation.
Cytomegalovirus (CMV) infection is endemic in Gambian infants, with 62% infected by 3 months and 85% by 12 months of age. We studied the CD8 T-cell responses of infants to CMV following primary infection. CMV-specific CD8 T cells, identified with tetramers, showed a fully differentiated phenotype (C...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2007
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| _version_ | 1826290874879836160 |
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| author | Miles, D van der Sande, M Jeffries, D Kaye, S Ismaili, J Ojuola, O Sanneh, M Touray, E Waight, P Rowland-Jones, S Whittle, H Marchant, A |
| author_facet | Miles, D van der Sande, M Jeffries, D Kaye, S Ismaili, J Ojuola, O Sanneh, M Touray, E Waight, P Rowland-Jones, S Whittle, H Marchant, A |
| author_sort | Miles, D |
| collection | OXFORD |
| description | Cytomegalovirus (CMV) infection is endemic in Gambian infants, with 62% infected by 3 months and 85% by 12 months of age. We studied the CD8 T-cell responses of infants to CMV following primary infection. CMV-specific CD8 T cells, identified with tetramers, showed a fully differentiated phenotype (CD28(-) CD62L(-) CD95(+) perforin(+) granzyme A(+) Bcl-2(low)). Strikingly, the overall CD8 T-cell population developed a similar phenotype following CMV infection, which persisted for at least 12 months. In contrast, primary infection was accompanied by up-regulation of markers of activation (CD45R0 and HLA-D) on both CMV-specific cells and the overall CD8 T-cell population and division (Ki-67) of specific cells, but neither pattern persisted. At 12 months of age, the CD8 T-cell population of CMV-infected infants was more differentiated than that of uninfected infants. Although the subpopulation of CMV-specific cells remained constant, the CMV peptide-specific gamma interferon response was lower in younger infants and increased with age. As the CD8 T-cell phenotype induced by CMV is indicative of immune dysfunction in the elderly, the existence of a similar phenotype in large numbers of Gambian infants raises the question of whether CMV induces a similarly deleterious effect. |
| first_indexed | 2024-03-07T02:50:53Z |
| format | Journal article |
| id | oxford-uuid:ada3bbbd-62c2-49f0-8935-a04641555bf7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:50:53Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:ada3bbbd-62c2-49f0-8935-a04641555bf72022-03-27T03:37:05ZCytomegalovirus infection in Gambian infants leads to profound CD8 T-cell differentiation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ada3bbbd-62c2-49f0-8935-a04641555bf7EnglishSymplectic Elements at Oxford2007Miles, Dvan der Sande, MJeffries, DKaye, SIsmaili, JOjuola, OSanneh, MTouray, EWaight, PRowland-Jones, SWhittle, HMarchant, ACytomegalovirus (CMV) infection is endemic in Gambian infants, with 62% infected by 3 months and 85% by 12 months of age. We studied the CD8 T-cell responses of infants to CMV following primary infection. CMV-specific CD8 T cells, identified with tetramers, showed a fully differentiated phenotype (CD28(-) CD62L(-) CD95(+) perforin(+) granzyme A(+) Bcl-2(low)). Strikingly, the overall CD8 T-cell population developed a similar phenotype following CMV infection, which persisted for at least 12 months. In contrast, primary infection was accompanied by up-regulation of markers of activation (CD45R0 and HLA-D) on both CMV-specific cells and the overall CD8 T-cell population and division (Ki-67) of specific cells, but neither pattern persisted. At 12 months of age, the CD8 T-cell population of CMV-infected infants was more differentiated than that of uninfected infants. Although the subpopulation of CMV-specific cells remained constant, the CMV peptide-specific gamma interferon response was lower in younger infants and increased with age. As the CD8 T-cell phenotype induced by CMV is indicative of immune dysfunction in the elderly, the existence of a similar phenotype in large numbers of Gambian infants raises the question of whether CMV induces a similarly deleterious effect. |
| spellingShingle | Miles, D van der Sande, M Jeffries, D Kaye, S Ismaili, J Ojuola, O Sanneh, M Touray, E Waight, P Rowland-Jones, S Whittle, H Marchant, A Cytomegalovirus infection in Gambian infants leads to profound CD8 T-cell differentiation. |
| title | Cytomegalovirus infection in Gambian infants leads to profound CD8 T-cell differentiation. |
| title_full | Cytomegalovirus infection in Gambian infants leads to profound CD8 T-cell differentiation. |
| title_fullStr | Cytomegalovirus infection in Gambian infants leads to profound CD8 T-cell differentiation. |
| title_full_unstemmed | Cytomegalovirus infection in Gambian infants leads to profound CD8 T-cell differentiation. |
| title_short | Cytomegalovirus infection in Gambian infants leads to profound CD8 T-cell differentiation. |
| title_sort | cytomegalovirus infection in gambian infants leads to profound cd8 t cell differentiation |
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