The chemical biology of human metallo-β-lactamase fold proteins.

The αββα metallo β-lactamase (MBL) fold (MBLf) was first observed in bacterial enzymes that catalyze the hydrolysis of almost all β-lactam antibiotics, but is now known to be widely distributed. The MBL core protein fold is present in human enzymes with diverse biological roles, including cell detox...

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Bibliographic Details
Main Authors: Pettinati, I, Brem, J, Lee, S, McHugh, P, Schofield, C
Format: Journal article
Language:English
Published: Elsevier 2016