Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis.

The extracellular signal-related kinases 1 and 2 (ERK1/2) are key proteins mediating mitogen-activated protein kinase signaling downstream of RAS: phosphorylation of ERK1/2 leads to nuclear uptake and modulation of multiple targets. Here, we show that reduced dosage of ERF, which encodes an inhibito...

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Détails bibliographiques
Auteurs principaux:	Twigg, S, Vorgia, E, McGowan, S, Peraki, I, Fenwick, A, Sharma, V, Allegra, M, Zaragkoulias, A, Sadighi Akha, E, Knight, S, Lord, H, Lester, T, Izatt, L, Lampe, A, Mohammed, SN, Stewart, F, Verloes, A, Wilson, L, Healy, C, Sharpe, P, Hammond, P, Hughes, J, Taylor, S, Johnson, D, Wall, SA
Format:	Journal article
Langue:	English
Publié:	2013

Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis.

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