Mass spectrometric assays monitoring the deubiquitinase activity of the SARS-CoV-2 papain-like protease inform on the basis of substrate selectivity and have utility for substrate identification

Mass spectrometric assays monitoring the deubiquitinase activity of the SARS-CoV-2 papain-like protease inform on the basis of substrate selectivity and have utility for substrate identification

The SARS-CoV-2 papain-like protease (PLpro) and main protease (Mpro) are nucleophilic cysteine enzymes that catalyze hydrolysis of the viral polyproteins pp1a/1ab. By contrast with Mpro, PLpro is also a deubiquitinase (DUB) that accepts post-translationally modified human proteins as substrates. Her...

Podrobná bibliografie
Hlavní autoři:	Brewitz, L, Chan, HTH, Lukacik, P, Strain-Damerell, C, Walsh, MA, Duarte, F, Schofield, CJ
Médium:	Journal article
Jazyk:	English
Vydáno:	Elsevier 2023

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