CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts.

CCN2 is induced by transforming growth factor-beta (TGFbeta) in fibroblasts and is overexpressed in connective tissue disease. CCN2 has been proposed to be a downstream mediator of TGFbeta action in fibroblasts; however, the role of CCN2 in regulating this process unclear. By using embryonic fibrobl...

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Hlavní autoři: Shi-wen, X, Stanton, L, Kennedy, L, Pala, D, Chen, Y, Howat, S, Renzoni, E, Carter, D, Bou-Gharios, G, Stratton, R, Pearson, J, Beier, F, Lyons, K, Black, C, Abraham, D, Leask, A
Médium: Journal article
Jazyk:English
Vydáno: 2006