Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials
<p>Methaemoglobin results from the oxidation of ferrous to ferric iron in the centre of the haem moiety of haemoglobin. The production of dose-dependent methaemoglobinaemia by 8-aminoquinoline antimalarial drugs appears to be associated with, but is not directly linked to, therapeutic efficacy...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Wiley
2022
|
| _version_ | 1797108957589798912 |
|---|---|
| author | White, NJ Watson, JA Baird, JK |
| author_facet | White, NJ Watson, JA Baird, JK |
| author_sort | White, NJ |
| collection | OXFORD |
| description | <p>Methaemoglobin results from the oxidation of ferrous to ferric iron in the centre of the haem moiety of haemoglobin. The production of dose-dependent methaemoglobinaemia by 8-aminoquinoline antimalarial drugs appears to be associated with, but is not directly linked to, therapeutic efficacy against latent <em>Plasmodium vivax</em> and <em>Plasmodium ovale</em> malarias (radical cure). Iatrogenic methaemoglobinaemia may be a useful pharmacodynamic measure in 8-aminoquinoline drug and dose optimization.</p> |
| first_indexed | 2024-03-07T07:35:17Z |
| format | Journal article |
| id | oxford-uuid:adf86e37-4e33-4534-99ec-9813baf54af1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:35:17Z |
| publishDate | 2022 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:adf86e37-4e33-4534-99ec-9813baf54af12023-02-22T14:28:56ZMethaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarialsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:adf86e37-4e33-4534-99ec-9813baf54af1EnglishSymplectic ElementsWiley2022White, NJWatson, JABaird, JK<p>Methaemoglobin results from the oxidation of ferrous to ferric iron in the centre of the haem moiety of haemoglobin. The production of dose-dependent methaemoglobinaemia by 8-aminoquinoline antimalarial drugs appears to be associated with, but is not directly linked to, therapeutic efficacy against latent <em>Plasmodium vivax</em> and <em>Plasmodium ovale</em> malarias (radical cure). Iatrogenic methaemoglobinaemia may be a useful pharmacodynamic measure in 8-aminoquinoline drug and dose optimization.</p> |
| spellingShingle | White, NJ Watson, JA Baird, JK Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials |
| title | Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials |
| title_full | Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials |
| title_fullStr | Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials |
| title_full_unstemmed | Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials |
| title_short | Methaemoglobinaemia and the radical curative efficacy of 8-aminoquinoline antimalarials |
| title_sort | methaemoglobinaemia and the radical curative efficacy of 8 aminoquinoline antimalarials |
| work_keys_str_mv | AT whitenj methaemoglobinaemiaandtheradicalcurativeefficacyof8aminoquinolineantimalarials AT watsonja methaemoglobinaemiaandtheradicalcurativeefficacyof8aminoquinolineantimalarials AT bairdjk methaemoglobinaemiaandtheradicalcurativeefficacyof8aminoquinolineantimalarials |