Viral vectored hepatitis C virus vaccines generate pan-genotypic T cell responses to conserved subdominant epitopes
<br><strong>Background: </strong>Viral genetic variability presents a major challenge to the development of a prophylactic hepatitis C virus (HCV) vaccine. A promising HCV vaccine using chimpanzee adenoviral vectors (ChAd) encoding a genotype (gt) 1b non-structural protein (ChAd-Gt...
Main Authors: | Donnison, T, von Delft, A, Brown, A, Swadling, L, Hutchings, C, Hanke, T, Chinnakannan, S, Barnes, E |
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Format: | Journal article |
Language: | English |
Published: |
Elsevier
2020
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