FLT3-ITDs instruct a myeloid differentiation and transformation bias in lymphomyeloid multipotent progenitors.

Whether signals mediated via growth factor receptors (GFRs) might influence lineage fate in multipotent progenitors (MPPs) is unclear. We explored this issue in a mouse knockin model of gain-of-function Flt3-ITD mutation because FLT3-ITDs are paradoxically restricted to acute myeloid leukemia even t...

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Bibliographic Details
Main Authors:	Mead, A, Kharazi, S, Atkinson, D, Macaulay, I, Pecquet, C, Loughran, S, Lutteropp, M, Woll, P, Chowdhury, O, Luc, S, Buza-Vidas, N, Ferry, H, Clark, SA, Goardon, N, Vyas, P, Constantinescu, SN, Sitnicka, E, Nerlov, C, Jacobsen, SE
Format:	Journal article
Language:	English
Published:	2013

FLT3-ITDs instruct a myeloid differentiation and transformation bias in lymphomyeloid multipotent progenitors.

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