The subcellular localisation of neuronal nitric oxide synthase determines the downstream effects of NO on myocardial function
Aim: In healthy hearts, the neuronal nitric oxide synthase (nNOS) is predominantly localised to the sarcoplasmic reticulum (SR), where it regulates the ryanodine receptor Ca2+ release channel (RyR2) and phospholamban (PLB) phosphorylation, and to a lesser extent to the sarcolemmal membrane where it...
Main Authors: | , , , , , , , , , |
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Format: | Journal article |
Published: |
Oxford University Press
2017
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