The subcellular localisation of neuronal nitric oxide synthase determines the downstream effects of NO on myocardial function

Aim: In healthy hearts, the neuronal nitric oxide synthase (nNOS) is predominantly localised to the sarcoplasmic reticulum (SR), where it regulates the ryanodine receptor Ca2+ release channel (RyR2) and phospholamban (PLB) phosphorylation, and to a lesser extent to the sarcolemmal membrane where it...

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Bibliographic Details
Main Authors: Carnicer, R, Suffredini, S, Liu, X, Reilly, S, Simon, J, Surdo, N, Zhang, Y, Lygate, C, Channon, K, Casadei, B
Format: Journal article
Published: Oxford University Press 2017