The subcellular localisation of neuronal nitric oxide synthase determines the downstream effects of NO on myocardial function

The subcellular localisation of neuronal nitric oxide synthase determines the downstream effects of NO on myocardial function

Aim: In healthy hearts, the neuronal nitric oxide synthase (nNOS) is predominantly localised to the sarcoplasmic reticulum (SR), where it regulates the ryanodine receptor Ca2+ release channel (RyR2) and phospholamban (PLB) phosphorylation, and to a lesser extent to the sarcolemmal membrane where it...

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Bibliographic Details
Main Authors:	Carnicer, R, Suffredini, S, Liu, X, Reilly, S, Simon, J, Surdo, N, Zhang, Y, Lygate, C, Channon, K, Casadei, B
Format:	Journal article
Published:	Oxford University Press 2017

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