A defect in the presentation of intracellular viral antigens is restored by interferon-gamma in cell lines with impaired major histocompatibility complex class I assembly.
Surface expression of the majority of class I major histocompatibility complex (MHC) heavy chains is known to require assembly with beta 2 microglobulin (beta 2m). To define other factors involved in class I MHC assembly, we have studied two tumor cell lines that are deficient in cell surface class...
Asıl Yazarlar: | Sibille, C, Gould, K, Hämmerling, G, Townsend, A |
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Materyal Türü: | Journal article |
Dil: | English |
Baskı/Yayın Bilgisi: |
1992
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