Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases.

BACKGROUND: We have recently shown that the severity of human colonic familial adenomatous polyposis (FAP) varies in a manner consistent with the action of modifier genes. These modifier genes may harbour common alleles which increase the risk of colorectal cancer (CRC) in the general population. A...

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Bibliographic Details
Main Authors: Crabtree, MD, Fletcher, C, Churchman, M, Hodgson, S, Neale, K, Phillips, R, Tomlinson, I
Format: Journal article
Language:English
Published: 2004