Two complement receptor one alleles have opposing associations with cerebral malaria and interact with α+thalassaemia

Malaria has been a major driving force in the evolution of the human genome. In sub-Saharan African populations, two neighbouring polymorphisms in the Complement Receptor One (CR1) gene, named Sl2 and McCb, occur at high frequencies, suggesting selection by malaria. Previous studies have been incon...

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Bibliographic Details
Main Authors:	Herbert Opi, D, Swann, O, Macharia, A, Uyoga, S, Band, G, Ndila, C, Harrison, E, Thera, M, Kone, A, Diallo, D, Doumbo, O, Lyke, K, Plowe, C, Moulds, J, Shebe, M, Mturi, N, Peshu, N, Maitland, K, Raza, A, Kwiatkowski, D, Rockett, K, Williams, T, Rowe, A
Format:	Journal article
Published:	eLife Sciences Publications 2018

Two complement receptor one alleles have opposing associations with cerebral malaria and interact with α+thalassaemia

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