Cardiac neuronal nitric oxide synthase isoform regulates myocardial contraction and calcium handling.

A neuronal isoform of nitric oxide synthase (nNOS) has recently been located to the cardiac sarcoplasmic reticulum (SR). Subcellular localization of a constitutive NOS in the proximity of an activating source of Ca2+ suggests that cardiac nNOS-derived NO may regulate contraction by exerting a highly...

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Bibliographic Details
Main Authors: Sears, C, Bryant, S, Ashley, E, Lygate, C, Rakovic, S, Wallis, H, Neubauer, S, Terrar, D, Casadei, B
Format: Journal article
Language:English
Published: 2003