Human macrophages induced in vitro by macrophage colony-stimulating factor are deficient in IL-12 production.
IL-12 is important for Th1 differentiation. Myeloid-derived antigen-presenting cells (APC) such as monocytes, macrophages (Mphi) and dendritic cells (DC) are believed to be major sources of IL-12 in vivo. We have compared IL-12 production of fresh monocytes with Mphi differentiated in vitro using ma...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1998
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