A framework for the definition and interpretation of the use of surrogate endpoints in interventional trials

A framework for the definition and interpretation of the use of surrogate endpoints in interventional trials

<p><strong>Background:&nbsp;</strong>Interventional trials that evaluate treatment effects using surrogate endpoints have become increasingly common. This paper describes four linked empirical studies and the development of a framework for defining, interpreting and reporting s...

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Main Authors: Ciani, O, Manyara, AM, Davies, P, Stewart, D, Weir, CJ, Young, AE, Blazeby, J, Butcher, NJ, Bujkiewicz, S, Chan, A-W, Dawoud, D, Offringa, M, Ouwens, M, Hróbjartssson, A, Amstutz, A, Bertolaccini, L, Bruno, VD, Devane, D, Faria, CDCM, Gilbert, PB, Harris, R, Lassere, M, Marinelli, L, Markham, S, Powers, JH, Rezaei, Y, Richert, L, Schwendicke, F, Tereshchenko, LG, Thoma, A, Turan, A, Worrall, A, Christensen, R, Collins, GS, Ross, JS, Taylor, RS
Format: Journal article
Language:English
Published: Elsevier 2023

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