Spatio-temporal modelling of phenotypic heterogeneity in tumour tissues and its impact on radiotherapy treatment

We present a mathematical model that describes how tumour heterogeneity evolves in a tissue slice that is oxygenated by a single blood vessel. Phenotype is identified with the stemness level of a cell and determines its proliferative capacity, apoptosis propensity and response to treatment. Our stud...

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Những tác giả chính: Celora, GL, Byrne, HM, Kevrekidis, PG
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: Elsevier 2022