Substrate specificity of cloned deacetoxycephalosporin C/deacetylcephalosporin C synthetase.

Substrate specificity of cloned deacetoxycephalosporin C/deacetylcephalosporin C synthetase.

Manylion Llyfryddiaeth
Prif Awduron:	Baldwin, J, Adlington, R, Crouch, N, Coates, J, Keeping, J, Schofield, C, Shuttleworth, W, Sutherland, J
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	1988

Eitemau Tebyg

Oxidation of deacetylcephalosporin C by deacetoxycephalosporin C/deacetylcephalosporin C synthase.
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Controlling the substrate selectivity of deacetoxycephalosporin/deacetylcephalosporin C synthase.
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Purification and initial characterization of an enzyme with deacetoxycephalosporin C synthetase and hydroxylase activities.
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STUDIES ON THE MECHANISM OF DEACETOXY DEACETYLCEPHALOSPORIN-C SYNTHASE USING CYCLOPROPYL SUBSTITUTED CEPHALOSPORIN PROBES
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STEPWISE HYDROGEN REMOVAL IN THE ENZYMATIC RING EXPANSION OF PENICILLIN-N TO DEACETOXYCEPHALOSPORIN-C
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Adipoyl-6-aminopenicillanic acid is a substrate for deacetoxycephalosporin C synthase (DAOCS)
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The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase.
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Alteration of the co-substrate selectivity of deacetoxycephalosporin C synthase. The role of arginine 258.
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Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS).
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Probing the penicillin sidechain selectivity of recombinant deacetoxycephalosporin C synthase.
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Studies on the active site of deacetoxycephalosporin C synthase.
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THE ENZYMATIC CONVERSION OF EXOMETHYLENE CEPHALOSPORIN-C INTO DEACETYL CEPHALOSPORIN-C AND THE ROLE OF MOLECULAR-OXYGEN IN CEPHALOSPORIN-C BIOSYNTHESIS
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The effect of cysteine mutations on recombinant deacetoxycephalosporin C synthase from S. clavuligerus.
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The kinetic properties of various R258 mutants of deacetoxycephalosporin C synthase.
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Studies on deacetoxycephalosporin C synthase support a consensus mechanism for 2-oxoglutarate dependent oxygenases.
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CEPHALOSPORIN-C BIOSYNTHESIS - STEREOCHEMISTRY OF THE INCORPORATION OF D,L,D-ALPHA-AMINODIPOYL-CYSTEINYL-(3S)-[2-2H,4-C-13]VALINE INTO BETA-LACTAM COMPOUNDS
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ENZYMATIC RING EXPANSION OF PENICILLINS TO CEPHALOSPORINS - SIDE-CHAIN SPECIFICITY
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CEPHALOSPORIN-C BIOSYNTHESIS - A BRANCHED PATHWAY SENSITIVE TO A KINETIC ISOTOPE EFFECT
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SYNTHESES OF [2-C-13] AND [1,2-C-13] LABELED ALPHA-KETOGLUTARIC ACID
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PENICILLIN BIOSYNTHESIS - DEPENDENCE OF SUBSTRATE STEREOCHEMISTRY ON THE MODE OF 2ND RING-CLOSURE
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Photoaffinity labelling of isopenicillin N synthetase.
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Photoaffinity labelling of isopenicillin N synthetase by laser-flash photolysis.
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Isolation and partial characterisation of ACV synthetase from Cephalosporium acremonium and Streptomyces clavuligerus. Evidence for the presence of phosphopantothenate in ACV synthetase.
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Isolation and partial characterisation of ACV synthetase from Cephalosporium acremonium and Streptomyces clavuligerus.
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CEPHALOSPORIN BIOSYNTHESIS - A BRANCHED PATHWAY SENSITIVE TO AN ISOTOPE EFFECT
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PENICILLIN BIOSYNTHESIS - ACTIVE SUBSTRATES DERIVED BY METHOXY SUBSTITUTION IN THE VALINYL RESIDUE OF THE NATURAL SUBSTRATE
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REVISED STRUCTURES FOR TU 1718B AND VALCLAVAM
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Module evolution and substrate specificity of fungal nonribosomal peptide synthetases involved in siderophore biosynthesis
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THE ENZYMATIC RING EXPANSION OF PENICILLINS TO CEPHALOSPORINS - SIDE-CHAIN SPECIFICITY
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