The mutagenic potential of 8-oxoG/single strand break-containing clusters depends on their relative positions

The biological consequences of clusters containing a single strand break and base lesion(s) remain largely unknown. In the present study we determined the mutagenicities of two- and three-lesion clustered damage sites containing a 1-nucleotide gap (GAP) and 8-oxo-7,8-dihydroguanine(s) (8-oxoG(s)) in...

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Bibliographic Details
Main Authors: Noguchi, M, Urushibara, A, Yokoya, A, O'Neill, P, Shikazono, N
Format: Journal article
Language:English
Published: 2012