A formal synthesis of (-)-pumiliotoxin C
An asymmetric synthesis of an advanced intermediate in the synthesis of natural (-)-pumiliotoxin C has been achieved in six steps and in 61% overall yield employing as the key step a highly diastereoselective lithium amide 1,4-conjugate addition to a dienoic ester derived from (R)-(+)-pulegone.
| Main Authors: | , |
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| Format: | Journal article |
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1996
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| _version_ | 1826291135498158080 |
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| author | Davies, S Bhalay, G |
| author_facet | Davies, S Bhalay, G |
| author_sort | Davies, S |
| collection | OXFORD |
| description | An asymmetric synthesis of an advanced intermediate in the synthesis of natural (-)-pumiliotoxin C has been achieved in six steps and in 61% overall yield employing as the key step a highly diastereoselective lithium amide 1,4-conjugate addition to a dienoic ester derived from (R)-(+)-pulegone. |
| first_indexed | 2024-03-07T02:54:51Z |
| format | Journal article |
| id | oxford-uuid:aee971e0-0318-49a1-8562-9098148c53a8 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T02:54:51Z |
| publishDate | 1996 |
| record_format | dspace |
| spelling | oxford-uuid:aee971e0-0318-49a1-8562-9098148c53a82022-03-27T03:45:59ZA formal synthesis of (-)-pumiliotoxin CJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:aee971e0-0318-49a1-8562-9098148c53a8Symplectic Elements at Oxford1996Davies, SBhalay, GAn asymmetric synthesis of an advanced intermediate in the synthesis of natural (-)-pumiliotoxin C has been achieved in six steps and in 61% overall yield employing as the key step a highly diastereoselective lithium amide 1,4-conjugate addition to a dienoic ester derived from (R)-(+)-pulegone. |
| spellingShingle | Davies, S Bhalay, G A formal synthesis of (-)-pumiliotoxin C |
| title | A formal synthesis of (-)-pumiliotoxin C |
| title_full | A formal synthesis of (-)-pumiliotoxin C |
| title_fullStr | A formal synthesis of (-)-pumiliotoxin C |
| title_full_unstemmed | A formal synthesis of (-)-pumiliotoxin C |
| title_short | A formal synthesis of (-)-pumiliotoxin C |
| title_sort | formal synthesis of pumiliotoxin c |
| work_keys_str_mv | AT daviess aformalsynthesisofpumiliotoxinc AT bhalayg aformalsynthesisofpumiliotoxinc AT daviess formalsynthesisofpumiliotoxinc AT bhalayg formalsynthesisofpumiliotoxinc |